研究方向/领域 :

碳氢键官能团化、电化学有机合成、药物化学、杂环小分子天然产物全合成

服务企业、产业相关工作成效、研究成果与荣誉：

梅汝槐博士毕业于德国哥廷根大学，获2018年四川省“千人计划”青年人才项目资助。在国际著名有机化学家Lutz Ackermann 教授的指导下，开展过渡金属催化碳氢键官能团化及电化学有机合成等相关研究，并以此为基础，开展了药物化学及杂环小分子天然产物全合成等相关工作。此外，梅汝槐博士先后于成都中医药大学中药学基地班专业及四川大学华西药学院天然药物化学专业获得理学学士及理学硕士学位，具有良好的药学教育背景。

在四川大学学习期间，其在徐亮教授指导下，从事极其富有挑战性的二萜生物碱天然产物全合成研究，并取得了较好的研究结果。梅汝槐博士在前期的研究工作中积累了良好的工作基础，相关研究成果发表于 J. Am. Chem. Soc., ACS Catal., Org. Lett., Chem. Commun., Chem. Eur. J., Adv. Synth. Catal.等国际高水平期刊上。

研究成果项目：

发表论文：

(14) S. Chandra Sau, R. Mei, J. Struwe, L. Ackermann, "Cobaltaelectro-Catalyzed C–H Activation with Carbon Monoxide or Isocyanides" ChemSusChem 2019, DOI: 10.1002/cssc.201900378.

(13) R. Mei, J. Koeller, L. Ackermann, "Electrochemical Ruthenium-Catalyzed Alkyne Annulations by C−H/Het−H Activation of Aryl Carbamates or Phenols in Protic Media" Chem. Commun. 2018, 54, 12879-12882. (IF= 6.064)

(12) R. Mei, N. Sauermann, J. C. A. Oliveira, L. Ackermann*, "Electro-Removable Traceless Hydrazides for Cobalt-Catalyzed Electro-Oxidative C–H/N–H Activation with Internal Alkynes" J. Am. Chem. Soc. 2018, 140, 7913-7921. 

(11) N. Sauermann, R. Mei, L. Ackermann*, "Electrochemical C–H Amination by Cobalt Catalysis in a Renewable Solvent" Angew. Chem. Int. Ed. 2018, 57, 5090-5094.

(10) R. Mei, S.-K. Zhang, L. Ackermann*, "Ruthenium(II)-Catalyzed C−H Alkynylation of Weakly-Coordinating Benzoic Acids" Org. Lett. 2017, 19, 3171-3174.

(9) R. Mei,' S.-K. Zhang,' L. Ackermann*, "Concise Synthesis of Lamellarin Alkaloids by C–H/N–H Activation: Evaluation of Metal Catalysts in Oxidative Alkyne Annulation" Synlett 2017, 28, 1715-1718. 'Co-first author.

(8) S. Nakanowatari, R. Mei, M. Feldt, L. Ackermann*, "Cobalt(III)-Catalyzed Hydroarylation of Allenes via C−H Activation" ACS Catal. 2017, 7, 2511-2515.

(7) R. Mei,' C. Zhu,' L. Ackermann*,"Ruthenium(II)-catalyzed C–H functionalizations on benzoic acids with aryl, alkenyl and alkynyl halides by weak-O-coordination" Chem. Commun. 2016, 52, 13171-13174.'Co-first author.

(6) W. Liu,' S. C. Richter,' R. Mei,' M. Feldt, L. Ackermann*,"Synergistic Heterobimetallic Manifold for Expedient Manganese(I)-Catalyzed C-H Cyanation" Chem. Eur. J. 2016, 22, 17958–17961. 'Co-first author.

(5) R. Mei, L. Ackermann*, "Cobalt-Catalyzed C‒H Functionalizations by Imidate Assistance with Aryl and Alkyl Chlorides" Adv. Synth. Catal. 2016, 358, 2443-2448. Selected as VIP paper and cover picture.

(4) R. Mei, H. Wang, S. Warratz, S. A. Macgregor*, L. Ackermann*, "Cobalt-Catalyzed Oxidase C–H/N–H Alkyne Annulation: Mechanistic Insights and Access to anti-Cancer Agents" Chem. Eur. J. 2016, 22, 6759-6763.

(3) R. Mei,' J. Loup,' L. Ackermann*, "Oxazolinyl-Assisted C−H Amidation by Cobalt(III) Catalysis" ACS Catal. 2016, 6, 793-797. 'Co-first author. (IF= 11.384)

(2) W. Ma, R. Mei, G. Tenti, L. Ackermann*, "Ruthenium(II)-Catalyzed Oxidative C–H Alkenylations of Sulfonic Acids, Sulfonyl Chlorides and Sulfonamides" Chem. Eur. J. 2014, 20, 15248-15251.

(1) R. Mei,' Z. Liu,' H. Cheng, L. Xu*, F. Wang, "Synthesis of the 10-Azatricyclo[3.3.2.04,8]decane Core of C20-Diterpenoid Alkaloid Racemulsonine via Iodine(III) Promoted Transannular Aziridination Reaction" Org. Lett. 2013, 15, 2206-2209. 'Co-first author.